Whether you’re listening through tinny iPhone headphones on your morning commute or crying at a John Mayer concert, there is a special place in our hearts for music. But what is the biological basis for that magical sensation we feel when listening to our favorite song?

Many scientists have theorized that the universal nature of music must have an evolutionary origin. Charles Darwin, the naturalist best known for his contributions to the science of evolution, suggested that humans use music to attract partners, which he explained this extensively his book The descent of man, and Selection in relation to sex. Darwin believed that we “endeavoured to charm each other with musical notes and rhythm.” This idea is comparable to the sexual selection processes shaped by birdsong, a well known mate selection theory. Other scientists have suggested that ‘feeling the rhythm’ is a way of synchronizing footsteps to avoid being heard by predators.

We may never know the exact evolutionary reason for our love of music, but researchers continue to investigate the neurochemical mechanisms that underlie the enjoyment of music. Much research has focused on the role of music on the brain’s reward system. The reward pathway begins in the center of the brain in a region called the ventral tegmental area. Here, special neurons release the neurotransmitterChemicals that cross some synapses and carry a signal to the... More dopamineA monoamine neurotransmitter. Dopamine is involved in many b... More, which gives you a jolt of pleasure and makes you feel good. In order to make sure you repeat this behavior in the future, the reward pathway is connected to areas of the brain that control memory and behavior, including the nucleus accumbens and prefrontal cortex. Not surprisingly, more dopamine is released when a person is listening to pleasant music.

But dopamine is not the only neurotransmitter involved in the enjoyment of music. Other studies have found that serotoninA monoamine neurotransmitter with a variety of functions. is also important. Drugs that act on serotonin are commonly used to treat depression. In fact, this neurotransmitter is associated with wakefulness and is important for the gut-brain interaction, so it is no surprise that serotonin levels in the nucleus accumbens rise when we are listening to music.

Of course, the reward and pleasure pathways are not the only neural networks activated when we listen to music. So what else might be going on? To answer this question, we must consider the fact that reward is experienced in two chemically distinct phases. The first ‘anticipatory phase,’ which is equivalent to ‘wanting,’ is driven by the dopaminergic neuronal pathways described above. The second ‘consummatory phase,’ which is the ‘liking’ part, is driven by a combination of dopaminergic pathways and opioid receptor activation. Opioids are substances that are medically used to relieve pain. These two phases activate different parts of the nucleus accumbens. Specifically, anticipatory pleasure is linked to a widely distributed network throughout the nucleus accumbens, while consummatory pleasure is linked to a more local aspect of this brain region (Footnote 1).

“…the sadness elicited when listening to music can be a feature of the pleasure itself…”

Despite this anatomical difference, the dopaminergic and opioid systems are directly linked during feelings of pleasure and reward. Therefore, it seems likely that opioids — in addition to dopamine — could be involved in the emotions we feel whilst listening to music. Earlier this year, a team of neuroscientists from McGill University conducted a study that explored how the brain’s endogenous (or self-made) opioids may be involved in controlling emotional responses to music.

In order to investigate the role of the opioid system in human subjects listening to music, the research team studied what happens when the opioid system is blocked using a drug called Naltrexone, or NTX. When NTX binds to opioid receptors, it acts as an antagonist, temporarily stopping the action of endogenous opioids that would act on this reward pathway. Previous studies have shown that administration of NTX reduces the rewarding feeling after physical activity, decreases the pleasant feeling after eating, and causes people to generally feel dampened highs and lows and reduced levels of joy and sadness. Based on this previous research, the team hypothesized that giving patients NTX would have the same general dampening effect on both the positive and negative emotional reactions to music, which can also be called musical anhedonia.

For their study, the research team ran a double-blind placebo controlled experiment, meaning that neither the team nor the participants knew if they were getting NTX or a sugar pill. Participants were asked to bring in two of their favorite music recordings that reliably produced intense feelings of pleasure for them. During the experiment, participants either listened to their self-selected music or ‘neutral’ music selected by the researchers. While they listened to the music, both objective and subjective measures were used to quantify their emotional response. These included measuring respiratory rates as well as using electromyography to measure the activity of muscles involved in smiling and frowning.

So what were the results? As expected, NTX reduced the extent of pleasure felt by participants when listening to music. Interestingly, NTX caused a great reduction in those feelings when participants were listening to their favorite songs compared to when they were listening to the control ‘neutral’ music. Importantly, not only did NTX reduce pleasurable feelings, it also reduced negative feelings too! Examination of the electromyograms revealed muscles involved in frowning were activated to a lesser extent in the presence of NTX. By dampening both the positive and negative feelings towards music, NTX had an overall ‘anhedonic’ effect on music.

The results of this study suggest that opioids are involved in regulating both positive and negative emotions that we experience when listening to music.

Although this may seem counter-intuitive since we are talking about pleasure from music, this idea also ties in with other research about the complex interactions that produce musical pleasure. In fact, previous research from the musical anhedonia research group suggests that the sadness elicited when listening to music can be a feature of the pleasure itself, perhaps by a provoking a shared feeling of sadness with other people and the composer of the music. This is why sadness whilst listening to music does not elicit a depressive neurochemical response, but is instead involved in an overall pleasurable experience and relates to the ‘chill’ sensation you get from certain songs.

Alas, the science of music is as complicated as a Bach fugue. Music elicits positive and negative emotions at the same time, while also producing a pleasurable sensation. In fact, this new field of research inspires other questions about the complex interactions of our emotions. Could we use what we’ve learned from music to explain other complex feelings, for example, nostalgia? Alongside these more abstract questions, the McGill University experiment shows that music may be governed by the same hedonic reward system as food, sex, and drugs, which have already been shown to elicit similar ‘anhedonic’ effects in the presence of NTX.

The fact that listening to music triggers such a well-defined neurochemical response may suggest an evolutionary origin for music, but it is hard to draw conclusions at this stage. This study has shown that the strong emotional response to music comprises positive and negative feelings – an advanced system that is likely to have evolutionary significance comparable to some of our most basic human needs like food and sex. It could be that the music reward pathway is hijacking an evolutionary system that was originally involved in something else related to these basic needs, such as responding to animal or human vocalizations.

Although ‘musical anhedonia’ doesn’t fully explain why we like music in the first place, it does explain how music sends shivers down the spine!

~

Footnote 1: Specifically, consummatory pleasure is linked to the rostro-dorsal quarter of the medial accumbens shell.

 

Artwork by Jooyeun Lee.

References:

Mallik, A., Chanda, M. L., & Levitin, D. J. (2017). Anhedonia to music and mu-opioids: Evidence from the administration of naltrexone. Scientific Reports, 7, 41952.

Amy Thomas

Amy Thomas

Amy is a Science Communication MSc student from Imperial College London and holds an undergraduate degree in Neuroscience. She hopes to communicate science through different mediums to spark interest in science and social topics. As well as writing, creating radio pieces and short films are areas of particular interest. Amy is also a musician and likes to compose music to complement her work.
Amy Thomas

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Amy Thomas

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Amy is a Science Communication MSc student from Imperial College London and holds an undergraduate degree in Neuroscience. She hopes to communicate science through different mediums to spark interest in science and social topics. As well as writing, creating radio pieces and short films are areas of particular interest. Amy is also a musician and likes to compose music to complement her work.

One Comment

  1. Thank you for this wonderful article, love the subject, ideas and that you studied neuroscience. I am crazy about Neuroscience and can’t get enough of it. Please keep driving these ideas and pushing every envelope.

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