The Departure of Skill Memories from Motor Cortex: Deeper Directions for Neuroscience

You probably have certain skills that I don’t.  Each of us, having spent enough time practicing something new, can become an expert.  A simple, ubiquitous example is driving a car with a manual transmission.  The precise sequence and timing of controlling the clutch, giving gas, and shifting the gears are challenging to coordinate when initially

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Smooth Move: How GABAergic Interneurons Regulate Skilled Motor Behavior

In early 2014, the American free-solo rock climber Alex Honnold climbed 2,500 feet of limestone without ropes.  The demanding route called El Sendero Luminoso in El Potrero Chico, Mexico required 3 hours of intense concentration and precise movements. One wrong move and the young climber would have fallen thousands of feet with catastrophic consequences. In

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(Transneuronal) Attack of the Mutant Huntingtin! Knowing Neurons

(Transneuronal) Attack of the Mutant Huntingtin!

Huntington’s disease (HD) is an incredibly debilitating neurodegenerative disorder. Currently, there is no treatment that effectively reverses the progression of the disease or delays its onset. Huntington’s is a particularly difficult diagnosis because it is an autosomal dominant degenerative disease, meaning that any child of an affected parent has a 50% chance of inheriting the

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Navigating A 3D World Knowing Neurons

Navigating a 3D World

The brain has an amazing ability to form internal maps of the world around it.  Knowing Neurons has previously written several articles about place cells in the hippocampus and how these neurons form internal maps of the world.  Think of it as thousands of neurons forming their own version of Google Maps inside your brain.

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