(Transneuronal) Attack of the Mutant Huntingtin! Knowing Neurons

(Transneuronal) Attack of the Mutant Huntingtin!

Huntington’s disease (HD) is an incredibly debilitating neurodegenerative disorder. Currently, there is no treatment that effectively reverses the progression of the disease or delays its onset. Huntington’s is a particularly difficult diagnosis because it is an autosomal dominant degenerative disease, meaning that any child of an affected parent has a 50% chance of inheriting the disease. Most children who inherit the disease have inevitably watched their parents battle with it.Continue reading

Forming Memories, One Neuron at a Time

On Monday, Knowing Neurons highlighted a recent research article that described a new miniature microscope that was small enough to sit on a mouse’s head and light enough to allow it to move freely!  This technology represents a great advancement for the field of neuroscience in general and place cell research, specifically!  For the first time, researchers at Stanford are able to literally watch neurons turn on and off in the hippocampus of a mouse, while it explores an open arena (video), all in real time. This technology adds a new twist on a classic way of studying how the brain maps out the world around us.Continue reading

You Are Here: Mapping The World With Neurons

“You are here.”  It’s the phrase that you’ll find on almost any map, punctuated with the ubiquitous oversized arrow.  It is the salient mark in a sea of confusing lines, shapes and labels that provides orientation and a sense of direction.  Since the release of Google Maps and smart phones, many of us have become accustomed to having a boundless map in the palms of our hands, one that constantly updates according to our position in the world, complete with a large arrow.  But in the absence of a map, directory, or an oversized arrow, how do you find your way?  Where is the internal map in your brain and how does it store information about the world in a sea of connected neurons?  Neuroscientists have been asking these questions for nearly thirty years now, and we only have a vague idea of how the brain forms internal representations of the outside world.Continue reading

Towards A Better Brain Model

One of the fundamental goals of cognitive and systems neuroscience is to create a computer program that can simulate the activity of the human brain, from single neurons, through network level processing, to influences on behavior.  The only problem is that the human brain contains almost 90 billion neurons with an estimated total of 100 trillion synapses!  As staggeringly large as those numbers are, researchers actually aren’t too far away from producing such a complex computer program.Continue reading

Bend it like Beckham: The Neuroscience Way

Life is a continuum of learning motor skills to achieve goals.  At a young age, children learn how sit up, walk, jump, and then cut with scissors.  Later, they may learn how to play soccer or piano, but they will probably not be as proficient as professional athletes and musicians unless they dedicate their lives to perfecting that skill.  So, how does practice make us more perfect?  Here are suggested guidelines for efficient motor skill learning that neuroscience studies have proposed.Continue reading

My, oh myelin!

How many neural processes are going on within your body as you read this sentence?  The answer to this question is hard to fathom, I know, but give it a shot.   Try to imagine all the physiological events that are being controlled by your nervous system at this very moment.  Our nervous systems control a dizzying array of sensory, motor, and cognitive processes simultaneously, without us granting them “permission” to do so.  In fact, most of our neural functions require no mental energy on our part whatsoever!  For this reason, it is extremely easy to take these basic processes for granted.  However, if we were to witness the suffering of an individual with multiple sclerosis, we might begin to appreciate these things a little more.Continue reading