The Epigenetic Legacy of Trauma

The evening of November 9th, 1938, began with typical fall solemnity for many Jews living across Germany: closing up their shops and businesses, returning home from school, and preparing family suppers. It would end with terror, as mobs ransacked storefronts, assaulted Jews on the street, and set fire to their homes. That terrible night would be known to history by the glittering debris of shattered windows lining the streets: “Kristallnacht.”

Kristallnacht, and the subsequent atrocities of Germany’s holocaust against the Jews, changed the world. Modernity had to forever acknowledge a surprising and abhorrent crime. Societies would undergo lasting changes, attempting to prevent such crimes, and the victims themselves, sadly, would suffer long-lasting impacts to their psyche.Continue reading

OCD Stress Knowing Neurons

A “Little Bit” of OCD: When Words Trivialize a Disorder

Sheldon Cooper, a beloved character in a television series, knocks on a door exactly three times before his roommate opens it — and if the door is opened earlier, he still persists his triad of door knocks. He fixates on occupying the exact same spot on the sofa every single time calling it “his” spot. As an audience, we watch his actions and surmise, “He has a little bit of OCD.”

The reality is: there is no such thing as a “little bit” when it comes to obsessive-compulsive disorders.Continue reading

What is Obsessive Compulsive Disorder?

Our thoughts are often mysterious to us. You probably don’t know why you suddenly think about a Komodo dragon while sitting in traffic or Citizen Kane while shopping for groceries. Such moments remind us that we are each the emergent property of an amazingly complex organ that never stops surprising us. Nonetheless, we usually feel in control of our thoughts. Even with the occasional unexpected thought, life continues as normal.Continue reading

The Slippery Slope of Dishonesty

A kid stealing candy in a convenience store grows up to be a convicted criminal. A husband who flirts with a coworker ends up as a serial cheater. A politician telling a few “white lies” to his or her constituents is eventually convicted of fraud. These are all extreme — but plausible — scenarios where dishonesty might escalate over time, resulting in dramatic and life-changing consequences. But how far does this slippery slope actually go? How can science help us answer this question?Continue reading

Mental Health is a Part of Health: A Conversation with Shekhar Saxena

In a recent presidential town hall, President Obama looked directly into the camera and made a powerful statement about mental health. “If something inside you feels like it’s wounded, it’s just like a physical injury. You’ve got to go get help,” said the leader of the free world.

Buried under the weight of a massive social stigma, seeking help or even acknowledging a mental illness can be an excruciating task. How, then, can we help ourselves and our loved ones achieve emotional and mental well-being?Continue reading

Copy Number Variants: A Window into Psychiatric Illness

The human genome consists of nearly 25,000 protein-coding genes – and a mutation in just one of these can have dramatic effects on our brains.  Remarkably, one tiny change in our genes (which can be as small as 0.000000025 cm!) can lead to visible changes in our behavior.  Schizophrenia, autism, bipolar disorder, and ADHD have all been linked to variations in our DNA.  But how do changes in our genetic code result in these complex psychiatric disorders?Continue reading

An Interview with Steve Silberman, Author of NeuroTribes

Ten minutes before I was scheduled to begin my interview with celebrated writer Steve Silberman, I still had not figured out which questions I wanted to ask him.  Staring down at a list of over 50 topics, I was overwhelmed by just how much there is to discuss when it comes to the history of the discovery of autism and misconceptions surrounding the diagnosis.  Silberman was one of the first members of the mainstream media to bring attention to the rise in autism diagnoses, and I wanted to know why autism had captured his interest.  Continue reading