Schizophrenia in a Vial? The Story of Ketamine

Note: Ketamine is a controlled substance in the US and many other countries. Do not use ketamine illicitly.

Imagine an injection that briefly gives you schizophrenia. Now imagine that this injection is all at once the same drug once abused by Steve-O of MTV’s Jackass, the same drug popped in karaoke bars in East Asia, the same drug given as anesthesia to animals and children, and the same drug that holds promise as an emergency antidote to suicidal thoughts.

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The Quest for a Successful TBI Treatment

A military veteran who survived a gunshot wound to the head suffers from frequent seizures and memory problems. A motorcycle crash survivor experiences chronic depression and is unable to hold a job. A 7-year-old boy who fell down the stairs as a toddler now has behavioral problems and difficulty focusing at school.

What do these people have in common? All these individuals are all afflicted with the long-term effects of traumatic brain injuries, or TBI.

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Risky Business, or Is It?

Biologist Marston Bates once described research as “the process of going up alleys to see if they are blind.” Bates was referring to the inherent uncertainty in predicting and managing the scientific process. Research funding, particularly for fundamental science, can be a seemingly risky investment because of the uncertainty of a study’s impact. However, it is imperative that fundamental science is not viewed as a luxury, but as a necessary investment that has the potential to yield significant returns.

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Mind the Gap: New Evidence on How Neurons Connect Left and Right Brain Halves

Our brains are split into two halves, a left hemisphere and a right hemisphere. While the left brain specializes in languages, the right brain specializes in faces. But the two halves don’t exist as two separate entities. Instead, both halves or hemispheres are connected at several points. These connections are important to transfer and coordinate information between hemispheres. But how do the correct neurons “know” if and where they should cross? The textbook model so far has described a positive chemical signal called Netrin that diffuses in the developing brain and guides crossing neurons. But new approaches to this question recently suggested a very different answer.

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How Neuroimaging Changes Our View of Science & Humanity

“The mind loves the unknown. It loves images whose meaning is unknown, since the meaning of the mind itself is unknown.” – René Magritte

Magritte’s comments on our fascination with the unknown rings true not just in artistic surrealism, but also in many of our scientific research endeavors. The human mind is continually fascinated with what it has yet to understand, and curiously enough, the human mind itself is one such mystery. However, recent efforts focused on imaging and analyzing the entire brain, performed by both scientists and artists alike, have helped shed some light on this mystery. With this new technology, however, comes the question of how neuroimaging can influence the perspectives of a sentient being. What does it mean to see a reflection of our own cognition, both for our understanding of science and for our perception of humanity and living creatures?

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Reading: The Brain’s Best Hijacker

What are you doing right now? I’m no psychic, but I can say for certain one thing that you’re doing: reading. You’re reading this sentence, word by word, and extracting meaning from little black lines of orthography, a fancy term for the rules of written language. If you really think about it, what you’re doing right now is quite difficult. What are the neural processes that enable us to read?

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Self Reflected: The Best of Neuroscience and Art

The phrase, “beauty is in the eye of the beholder” seems especially true for scientists. What we study becomes not only intellectually beautiful, but also literally beautiful: the form is pleasing to the eyes. Appreciation and endearment develops over time as scientists gaze on their subject for hours, days, years. In fact, research by the psychologist Robert Zajonc shows that the more familiar you are with something, the more likely you are to enjoy it.

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