Epigenetics change which genes are active and which are inactive. Research over the past few years has shown that these changes are important for protecting the brain from neurodegeneration and injury. A review paper came out on May 18th in the journal Nature Reviews Neuroscience that summarizes this research. Check out the infographic for a description of the review paper.
The human genome consists of nearly 25,000 protein-coding genes – and a mutation in just one of these can have dramatic effects on our brains. Remarkably, one tiny change in our genes (which can be as small as 0.000000025 cm!) can lead to visible changes in our behavior. Schizophrenia, autism, bipolar disorder, and ADHD have all been linked to variations in our DNA. But how do changes in our genetic code result in these complex psychiatric disorders?Continue reading
We all know too much sugar is bad for us. But did you know that having unfettered access to sugar might produce brain changes similar to highly stressful situations, such as neglect or abuse? A recent study published in Frontiers in Molecular Neuroscience comparing the effects of unlimited sugar availability and the effects of early life stress in rats might suggest just that.Continue reading
Hsu P. & Feng Zhang (2014). Development and Applications of CRISPR-Cas9 for Genome Engineering, Cell, 157 (6) 1262-1278. DOI: http://dx.doi.org/10.1016/j.cell.2014.05.010
Fineran P.C. (2014). Gene regulation by engineered CRISPR-Cas systems, Current Opinion in Microbiology, 18 83-89. DOI: http://dx.doi.org/10.1016/j.mib.2014.02.007
Doudna J.A. (2014). The new frontier of genome engineering with CRISPR-Cas9, Science, 346 (6213) 1258096-1258096. DOI: http://dx.doi.org/10.1126/science.1258096
Take your wildest guess. How many neurons make up the human brain? You’re not guessing wild enough if you said anything less than a trillion. The circuitry of the human brain consists of a quadrillion (1015) synapses. These neural circuits aren’t necessarily hard-wired and have the capacity to be re-wired in response to experience. In our interview with Dr. Kelsey C. Martin, Professor of Psychiatry and Biological Chemistry at University of California, Los Angeles, we discuss the long-lasting forms of plasticity that enable memories to be formed. During the course of our conversation, Dr. Martin shares stories from her time in the Peace Corps. and discusses what it was like to study memory formation as a post-doc in the lab of the Nobel Prize winning scientist, Eric Kandel. In this highly anticipated interview from Knowing Neurons, we sit down with Dr. Martin to get advice on what it takes to become a Principal Investigator, to discuss her upcoming Presidential lecture at SFN, and to find out exactly what this English major turned M.D./Ph.D. is currently reading.Continue reading
Huntington’s disease (HD) is an incredibly debilitating neurodegenerative disorder. Currently, there is no treatment that effectively reverses the progression of the disease or delays its onset. Huntington’s is a particularly difficult diagnosis because it is an autosomal dominant degenerative disease, meaning that any child of an affected parent has a 50% chance of inheriting the disease. Most children who inherit the disease have inevitably watched their parents battle with it.Continue reading
The potential to manipulate DNA sequences and insert genes with the use of zinc finger nucleases (ZFNs) has huge implications for human genetic disease therapeutics. One exciting example is a clinical trial that is using ZFN technology to disrupt the gene for the HIV co-receptor CCR5 and protect against the progression of HIV to AIDS. As shown in the infographic below, ZFNs introduce DNA sequence changes into individual genes to create deletions, insertions, or base substitutions. ZFN technology is a powerful tool that enables scientists to study the effects of these changes on gene function and may one day be used to treat human genetic disorders.Continue reading
More than a decade has passed since President Clinton first announced that the human genome project was successfully completed:
We are here to celebrate the completion of the first survey of the entire human genome. Without a doubt, this is the most important, most wondrous map ever produced by human kind.