Science Fiction, Serendipity and Interneuron Specification: A Conversation with Dr. Gordon J. Fishell

Gordon FishellIt is easy to assume that if a car has a gas pedal, it needs to have brakes, and similarly, if our brain has excitatory neurons, it needs inhibition too. For a long time, the field of neuroscience had thought of inhibitory interneurons as the “brakes” of the brain, providing suppression to neuronal activity. However, in my conversation with Dr. Gordon J. Fishell, I learned that interneurons are far more fascinating cell types than merely being inhibitory! Their multifarious morphology can be attributed to a palette of functions in brain developmental and regulation.Continue reading