When Cellular Power Plants Fail

Humans normally have 23 pairs of chromosomes, but sometimes an error during cell division causes there to be an abnormal number of chromosomes. One of the most common chromosome abnormalities in humans is Down syndrome (DS). In most cases, this occurs when there is an extra copy of chromosome 21, which is called Trisomy 21. It is typically associated with distinct facial features, impaired cognitive functions, and stunted physical growth.  Surprisingly, almost all people with DS also exhibit clinical symptoms of Alzheimer’s disease (AD) 10-20 years before it usually occurs in the general population. So, what is the link between DS and AD?Continue reading

A Close Look into the Alzheimer’s Brain

Your brain is able to store massive amounts of memories throughout your lifetime.  There are cases, however, in which this ability progressively degrades and eventually disappears, giving way to problems with thinking, reasoning, and remembering.  When these symptoms occurs faster than normal aging, it is termed dementia.  Alzheimer’s disease (AD) is the most common form of brain function loss, and its neuropathology are summarized here.Continue reading