Final Decision? Why the Brain Keeps on Changing its Mind

Benjamin Franklin once quipped: ‘There are three things extremely hard: steel, a diamond, and to know oneself.’ Every decision we make, from pinpointing the source of a faint sound to choosing a new job, comes with a degree of confidence that we have made the right call. If confidence is sufficiently low, we might change our minds and reverse our decision. Now scientists are using these choice reversals to study the first inklings of self-knowledge. Changes of mind, it turns out, reflect a precisely tuned process for monitoring our stream of thoughts.Continue reading

Science Fiction, Serendipity and Interneuron Specification: A Conversation with Dr. Gordon J. Fishell

Gordon FishellIt is easy to assume that if a car has a gas pedal, it needs to have brakes, and similarly, if our brain has excitatory neurons, it needs inhibition too. For a long time, the field of neuroscience had thought of inhibitory interneurons as the “brakes” of the brain, providing suppression to neuronal activity. However, in my conversation with Dr. Gordon J. Fishell, I learned that interneurons are far more fascinating cell types than merely being inhibitory! Their multifarious morphology can be attributed to a palette of functions in brain developmental and regulation.Continue reading