To make a working nervous system, only two forces are necessary: The process by which a presynaptic neuron makes the postsyna... and The process by which a presynaptic neuron makes the postsyna.... Excitatory signaling from one cell to the next makes the latter cell more likely to fire. Inhibitory signaling makes the latter cell less likely to fire. At chemical synapses in the brain, glutamate and GABA (gamma-aminobutyric acid) are transmitters for excitation and inhibition, respectively. Admittedly, their names don’t quite evoke symmetry — one being evocative of cheap food seasoning and the other of a Swedish pop band. Yet, The principal excitatory neurotransmitter in the nervous sys... and Gamma aminobutryic acid, the principal inhibitory neurotrans... are the Ying and Yang of the brain. A monoamine neurotransmitter. Dopamine is involved in many b..., A monoamine neurotransmitter with a variety of functions., norepinephrine, and other more celebrated brain chemicals have earned their fame as transmitters with much more specialized effects. But the bread and butter of the brain are unquestionably glutamate and GABA. In principle, a nervous system of only a handful of neurons and two transmitters — excitatory and inhibitory — is possible.
The balance between neural excitation and neural inhibition is crucial to healthy cognition and behavior. A brain dominated by glutamate would only be capable of exciting itself in repeated bursts of activity, similar to an epileptic seizure. Conversely, a brain dominated by GABA would only be capable of quiet whispers of activity, with little Coordination in time between components of a system such as ... necessary for meaningful communication between brain areas. Healthy brain activity thrives in the middle area between these two extremes, where a balance between excitation and inhibition generates complex patterns of activity. Thus, a seemingly simple nervous system formed with only glutamate and GABA nonetheless results in highly complex activity.
Similarly, a seemingly simple mixture of chemicals in a Petri dish can give rise to highly complex chemical reaction patterns, such as oscillating spiral waves, when a chemical that excites the reaction and a chemical that inhibits the reaction are both present. This general type of reaction, called the Belousov–Zhabotinsky reaction, has even been studied as a model for how neural networks process information, since the reaction’s complexity is governed by similar principles.
Because complex patterns of brain activity are thought to underlie flexible behavior and cognition, the ratio between excitation and inhibition — referred to as E/I balance — is becoming increasingly recognized as a crucial measure for assessing the fitness of any brain. Schizophrenia, for example, has been associated with a low E/I ratio caused by weakly active glutamate receptors. Autism, on the other hand, has been associated with a high E/I ratio caused by weakly active GABA receptors. Even greater excesses of excitation or inhibition may result in epileptic seizures or brain coma, respectively. In fact, individuals with autism are far more likely to have epilepsy — a condition that causes seizures — than the average person, suggesting that both autism and A nervous system disorder that causes seizures due to abnorm... are rooted in a high E/I ratio.
How does the synergy between excitation and inhibition work? Both excitation and inhibition, acting alone, attract the brain toward distinct patterns of relatively simple activity. The balance of both creates a critical state, like the boundary between a gas and a liquid. Outside the brain, many critical states are unstable, like a pencil that is balanced vertically on its tip but falls over after any further change in its position. Yet surprisingly, critical states in the brain are often self-maintained and robust to further changes. For instance, after synaptic input to a neural network has generated a critical state, further synaptic input maintains the critical state rather than pushing the network into a simple, stable pattern. For this reason, the phenomenon is called self-organized criticality, or SOC, a term for the concept developed by physicists Per Bak, Chao Tang, and Kurt Wiesenfeld of the Brookhaven National Laboratory in New York.
SOC is thought to be important for brain function because it allows the brain a certain degree of flexibility. Just as a critical substance might flexibly switch between a gas and a liquid state, SOC might allow the brain to visit many different activity states. Wherever SOC is observed in nature, it seems to produce complex activity across many temporal and spatial scales as a result of a slow process that builds energy and a fast process that dissipates energy.
… just as many spiritual practices advocate for maintaining an “inner balance,” a physical balance between opposing forces appears central to maintaining a healthy brain.
To better understand SOC, Bak and his colleagues imagined a familiar scenario: building a sandpile at the beach. The sandpile grows bigger until its slope reaches a certain steepness that results in a critical state. Adding more sand then triggers avalanches of sizes ranging from a few grains to sizable portions of the sandpile itself. In fact, the critical state persists even as you add more sand — it is truly self-organized.
The two competing processes in this example are the slow process of adding sand, which builds energy, and the fast process resulting from the force of gravity overcoming the force friction, which dissipates energy. Perhaps this example feels far removed from the brain. But the slow process of adding sand is actually analogous to adding excitatory synaptic input in a neural network. Similarly, the fast process of gravity overcoming friction is analogous to neural excitation overcoming neural inhibition and triggering bursts of firing — neuronal avalanches. Sandpile avalanches follow the same pattern observed in electrical brain recordings: activity is observed at all scales and frequencies, a result of delicate E/I balance.
In fact, we can alter the sandpile model to simulate disease states where excitation and inhibition are unbalanced. Imagine building a pile from glass beads rather than grains of sand. The smooth beads do not stick well, and the fragile pile collapses like a Jenga tower once it reaches a critical mass, never achieving true self-organized criticality. This is analogous to state of excessive neural excitation: synaptic inhibition is too weak to stop the storms of excitatory bursting that interrupt complex signaling and form seizures. Conversely, imagine building a sandpile using wet sand: the wet sand is sticky, resulting in few avalanches as the cohesiveness of the sand is too high. This is analogous to a state of excessive neural inhibition: excitatory drive cannot overcome the suffocating grip of synaptic inhibition, hampering neural computations that depend on complex signaling.
Because electrical brain activity can easily be observed by placing electrodes on the scalp (EEG), it is possible for researchers and clinicians to infer E/I balance without directly probing cells in the brain. For example, epileptiform discharges—bursts of disruptive excitement—are clear signatures of a high E/I ratio. These discharges may indicate that the brain has been pushed past criticality to a supercritical state. Though traditionally associated with epilepsy, epileptiform discharges may also occur in the EEGs of patients who have never had a single An event that is associated with uncontrolled and excessive ... before. An emerging concept of “epilepsy spectrum disorders” seeks to frame mental illnesses, such as panic disorder, in the same context as epilepsy. Dr. Nash N. Boutros at the University of Missouri, Kansas City is exploring epileptiform discharges in patients with panic attacks as possible indicators of the same high E/I ratio that causes epilepsy. If panic disorders and epilepsy share a common cause, they might both be treatable with antiepileptic drugs. While such drugs generally treat seizures, they are believed to decrease neuronal excitability and have also been approved by the FDA to treat bipolar disorder, a A mental illness that can be treated by a psychiatrist. where patients experience states of both elevated and lowered mood.
In the near future, drugs that alter neuronal excitability may show promise in guiding the diseased brain towards E/I balance. Indeed, just as many spiritual practices advocate for maintaining an “inner balance,” a physical balance between opposing forces appears central to maintaining a healthy brain. The synergy between opposites observed in the brain reminds us that complexity requires a balance. While empirical evidence has shown that brain size or brain mass is not the best measure of brain fitness, E/I balance might instead contend for that title. One day, a checkup at the doctor’s office might not just involve taking your pulse, height, and weight, but also an Electroencephalogram, a technique that places electrodes on ... reading of your E/I ratio.
Written by Joel Frohlich.
Images by Kayleen Schreiber.
This article was also featured in Psychology Today.
Harrington, Adam J., et al. “C. elegans as a model organism to investigate molecular pathways involved with Neurodegenerative disease where dopaminergic neurons of the ....” Developmental dynamics 239.5 (2010): 1282-1295.
Gruenert, Gerd, Peter Dittrich, and Klaus-Peter Zauner. “Artificial wet neuronal networks from compartmentalised excitable chemical media.” ERCIM NEWS 85 (2011): 30-32.Vanag, Vladimir K., and Irving R. Epstein. “Excitatory and inhibitory coupling in a one-dimensional array of Belousov-Zhabotinsky micro-oscillators: Theory.” Physical Review E 84.6 (2011): 066209.
Tompkins, Nathan, et al. “Testing Turing’s theory of morphogenesis in chemical cells.” Proceedings of the National Academy of Sciences 111.12 (2014): 4397-4402.
Buzsaki, Gyorgy. Rhythms of the Brain. Oxford University Press, 2006.
Bak, Per, Chao Tang, and Kurt Wiesenfeld. “Self-organized criticality: An explanation of the 1/f noise.” Physical review letters 59.4 (1987): 381.
Bak, Per. “How nature works: the science of self-organized criticality.” Nature 383.6603 (1996): 772-773.
Tetzlaff, Christian, et al. “Self-organized criticality in developing neuronal networks.” PLoS Comput Biol 6.12 (2010): e1001013.
Boutros, Nash N., et al. “Epilepsy spectrum disorders: A concept in need of validation or refutation.” Medical hypotheses 85.5 (2015): 656-663.
Boutros, Nash N., et al. “Predictive value of isolated epileptiform discharges for a favorable therapeutic response to antiepileptic drugs in nonepileptic psychiatric patients.” Journal of Clinical Neurophysiology 31.1 (2014): 21-30.
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